Construction of fatty acid derivatives from rubber seed oil as α-glucosidase inhibitors based on rubber seed oil
نویسندگان
چکیده
Abstract Natural free fatty acids show inhibitory effects on α-glucosidase and can hence have potential applications in diabetes treatment. This study indicated that the effect of showed a significant negative correlation with affinity energy (− 0.87) melting point 0.88). Guided by this relationship, two promotion strategies hydration esterification were put forward to increase α-glucosidase. The import an extra hydroxy group into C=C bond acids, will enhance interaction α-glucosidase, while lower promote effect. Hydroxy acid isopropyl esters possessed higher than natural acids. Then, rubber seed oil was modified novel derivatives IC50 products isopropanol 0.42 ± 0.01 μM 0.57 μM, respectively. result reveals feasible route construct from Graphical
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ژورنال
عنوان ژورنال: Bioresources and Bioprocessing
سال: 2022
ISSN: ['2197-4365']
DOI: https://doi.org/10.1186/s40643-022-00492-9